Comparison of left- and right-sided colorectal cancer to explore prognostic signatures related to pyroptosis.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common malignancies, and pyroptosis exerts an immunoregulatory role in CRC. Although the location of the primary tumor is a prognostic factor for patients with CRC, the mechanisms of pyroptosis in left- and right-sided CRC remain unclear.

Methods

Expression and clinical data were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. Differences in clinical characteristics, immune cell infiltration, and somatic mutations between left- and right-sided CRC were then compared. After screening for differentially expressed genes, Pearson correlation analysis was performed to select pyroptosis-related genes, followed by a gene set enrichment analysis. Univariate and multivariate Cox regression analyses we

SUBMITTER: Luo S 

PROVIDER: S-EPMC10987941 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature