Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification.

ABSTRACT:

Background

Hepatic fibrosis is caused by various liver diseases and eventually develops into liver cancer. There is no specific drug approved for the treatment of hepatic fibrosis in the world. Acacetin (AC), a natural flavonoid, is widely present in nature in various plants, such as black locust, Damiana, Silver birch. It has been reported that acacetin can inhibit the proliferation of cancer cells and induce apoptosis.

Purpose

In this study, we investigated the effect of acacetin on hepatic stellate cell apoptosis, thereby improving hepatic fibrosis, and combined experimental validation and molecular docking to reveal the underlying mechanism.

Result

First, we discovered that acacetin inhibited hepatic stellate cell proliferation as well as the expression of fibrosi

SUBMITTER: Hu X 

PROVIDER: S-EPMC10988056 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature