Circulating immune cell landscape and T-cell abnormalities in patients with moyamoya disease.

ABSTRACT:

Background

Moyamoya disease (MMD) stands as a prominent cause of stroke among children and adolescents in East Asian populations. Although a growing body of evidence suggests that dysregulated inflammation and autoimmune responses might contribute to the development of MMD, a comprehensive and detailed understanding of the alterations in circulating immune cells associated with MMD remains elusive.

Methods

In this study, we employed a combination of single-cell RNA sequencing (scRNA-seq), mass cytometry and RNA-sequencing techniques to compare immune cell profiles in peripheral blood samples obtained from patients with MMD and age-matched healthy controls.

Results

Our investigation unveiled immune dysfunction in MMD patients, primarily characterized by perturbations i

SUBMITTER: Ge P 

PROVIDER: S-EPMC10988118 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature