The expression of trefoil factor family member 2 in increased at an acidic pH.

ABSTRACT: Trefoil factor family member 2 (Tff2) is significantly involved in intestinal tumor growth in Apc^Min/+ mice, which can be used as a human colon cancer model. TFF2, which encodes TFF2 (spasmolytic protein 1) is highly expressed in human cancer tissues, including the pancreas, colon and bile ducts, as well as in normal gastric and duodenum tissues. By contrast, TFF2 exhibits low expression levels in other normal tissues, including the small and large intestine. Furthermore, TFF2 expression has not been detected in DLD-1 cells, a cell line derived from human colon cancer. What induces TFF2 expression in normal and tumor cells is still unknown. Highly malignant tumor tissues are characterized by higher temperatures and lower pH (6.2-6.9) tha

SUBMITTER: Masumoto Y 

PROVIDER: S-EPMC10988190 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature