Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.

ABSTRACT:

New findings

What is the central question of this study? What are the physiological roles of cardiomyocyte-derived tetrahydrobiopterin (BH4) in cardiac metabolism and stress response? What is the main finding and its importance? Cardiomyocyte BH4 has a physiological role in cardiac metabolism. There was a shift of substrate preference from fatty acid to glucose in hearts with targeted deletion of BH4 synthesis. The changes in fatty-acid metabolic profile were associated with a protective effect in response to ischaemia-reperfusion (IR) injury, and reduced infarct size. Manipulating fatty acid metabolism via BH4 availability could play a therapeutic role in limiting IR injury.

Abstract

Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which

SUBMITTER: Chu SM 

PROVIDER: S-EPMC10988529 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature