Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model.

ABSTRACT: Heat stroke is a perilous condition marked by severe hyperthermia and extensive multiorgan dysfunction, posing a considerable risk of mortality if not promptly identified and treated. Furthermore, the complex biological mechanisms underlying heat stroke-induced tissue and cell damage across organ systems remain incompletely understood. This knowledge gap has hindered the advancement of effective preventive and therapeutic strategies against this condition. In this narrative review, we synthesize key insights gained over a decade using a translational baboon model of heat stroke. By replicating heat stroke pathology in a non-human primate species that closely resembles humans, we have unveiled novel insights into the pathways of organ injury and cell death elicited by this condition. Here,

SUBMITTER: Abdullah M 

PROVIDER: S-EPMC10988686 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature