Quercetin inhibition of porcine intestinal alpha coronavirus in vitro and in vivo.

ABSTRACT:

Background

Porcine acute diarrhea syndrome coronavirus (SADS-CoV) is one of the novel pathogens responsible for piglet diarrhea, contributing to substantial economic losses in the farming sector. The broad host range of SADS-CoV raises concerns regarding its potential for cross-species transmission. Currently, there are no effective means of preventing or treating SADS-CoV infection, underscoring the urgent need for identifying efficient antiviral drugs. This study focuses on evaluating quercetin as an antiviral agent against SADS-CoV.

Results

In vitro experiments showed that quercetin inhibited SADS-CoV proliferation in a concentration-dependent manner, targeting the adsorption and replication stages of the viral life cycle. Furthermore, quercetin disrupts the regulation of

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10988794 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature