Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients.

ABSTRACT:

Background

Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loading conditions during mechanical ventilation and to establish whether dyssynchronous diaphragm contractions are associated with the development of impaired diaphragm dysfunction.

Methods

In patients receiving invasive mechanical ventilation for pneumonia, septic shock, acute respiratory distress syndrome, or acute brain injury, airway flow and pressure and diaphragm electrical activity (Edi) were recorded hourly around the clock for up to 7 days. Dyssynchronous post-inspiratory diaphragm loading was defined based on the duration of neural inspiration after expi

SUBMITTER: Coiffard B 

PROVIDER: S-EPMC10988824 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature