Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study.

ABSTRACT:

Background

Vitamin D deficiency in critically ill patients is associated with poor outcomes, and vitamin D supplementation is recommended for patients with chronic kidney disease. Whether acute kidney injury (AKI) is associated with altered Vitamin D metabolism is unknown. We aimed to compare the longitudinal profiles of serum 25(OH)D and 1,25(OH)₂D concentrations in critically ill patients with and without moderate to severe AKI and explore the impact of renal recovery and parathyroid hormone (PTH).

Methods

In this prospective, observational study in two centres in the UK, critically ill patients with and without AKI underwent serial measurement of serum 25(OH)D and 1,25(OH)₂D and plasma PTH concentrations for 5 days. Linear mixed model analysis and se

SUBMITTER: Cameron LK 

PROVIDER: S-EPMC10988948 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature