<i>Pseudomonas aeruginosa</i> ventricular assist device infections: findings from ineffective phage therapies in five cases.

ABSTRACT: Left ventricular assist devices (LVAD) are increasingly used for management of heart failure; infection remains a frequent complication. Phage therapy has been successful in a variety of antibiotic refractory infections and is of interest in treating LVAD infections. We performed a retrospective review of four patients that underwent five separate courses of intravenous (IV) phage therapy with concomitant antibiotic for treatment of endovascular Pseudomonas aeruginosa LVAD infection. We assessed phage susceptibility, bacterial strain sequencing, serum neutralization, biofilm activity, and shelf-life of phage preparations. Five treatments of one to four wild-type virulent phage(s) were administered for 14-51 days after informed consent and regulatory approval. There was no successful

SUBMITTER: Aslam S 

PROVIDER: S-EPMC10989018 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature