Bimodal distribution of azole susceptibility in <i>Sporothrix brasiliensis</i> isolates in Brazil.

ABSTRACT: Sporothrix brasiliensis is an emerging zoonotic fungal pathogen that can be difficult to treat. Antifungal susceptibility testing was performed on the mold phase of a convenience sample of 61 Sporothrix spp. isolates from human and cat sporotrichosis cases in Brazil using the Clinical and Laboratory Standards Institute standard M38. A bimodal distribution of azole susceptibility was observed with 50% (28/56) of S. brasiliensis isolates showing elevated itraconazole minimum inhibitory concentrations ≥16 µg/mL. Phylogenetic analysis found the in vitro resistant isolates were not clonal and were distributed across three different S. brasiliensis clades. Single nucleotide polymorphism (SNP) analysis was performed to identify potential mechanisms of in vitr

SUBMITTER: Ribeiro Dos Santos A 

PROVIDER: S-EPMC10989022 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature