MetaSVs: A pipeline combining long and short reads for analysis and visualization of structural variants in metagenomes.

ABSTRACT: Structural variants (SVs, including large-scale insertions, deletions, inversions, and translocations) significantly impact the functions of genes in the microbial genome, and SVs in the microbiome are associated with diverse biological processes and human diseases. With the advancements in sequencing and bioinformatics technologies, increasingly, sequencing data and analysis tools are already being extensively utilized for microbiome SV analyses, leading to a higher demand for more dedicated SV analysis workflows. Moreover, due to the unique detection biases of various sequencing technologies, including short-read sequencing (such as Illumina platforms) and long-read sequencing (e.g., Oxford Nanopore and PacBio), SV discovery based on multiple platforms is necessary to comprehensively ide

SUBMITTER: Li Y 

PROVIDER: S-EPMC10989790 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature