Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice.

ABSTRACT: Mass cadmium (Cd) poisoning is a serious health problem in many parts of the world. We propose that dietary intervention can be a practical solution to this problem. This study aimed to identify effective dietary products from traditional Chinese herbs that can detoxify Cd. Five candidate herbal foods with detoxifying potential were selected and subjected to mouse toxicological tests. The chemical composition and dose-response effects of licorice on mouse hepatocytes were determined. Licorice was selected for further tests to examine its effects on growth, tissue Cd accumulation, and gut and liver fitness of mice. The expression of hepatic metallothionein (Mt) genes was quantified in vitro in hepatocytes and in vivo in liver tissues of mice. The results showed that licorice dietary interve

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10989944 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature