High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals.

ABSTRACT:

Background

There is a suite of chemicals, including metals, pesticides, and personal care product compounds, which are commonly detected at high levels in US Center for Disease Control's National Health and Nutrition Examination Survey (NHANES) chemical biomarker screens. Whether these chemicals influence development of breast cancer is not well understood.

Objectives

The objectives were to perform an unbiased concentration-dependent assessment of these chemicals, to quantify differences in cancer-specific genes and pathways, to describe if these differences occur at human population-relevant concentrations, and to specifically test for differences in markers of stemness and cellular plasticity.

Methods

We treated nontumorigenic mammary epithelial cells, MCF10A, with

SUBMITTER: Sala-Hamrick KE 

PROVIDER: S-EPMC10990114 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature