Modeling the mosaic structure of bacterial genomes to infer their evolutionary history.

ABSTRACT: The chronology and phylogeny of bacterial evolution are difficult to reconstruct due to a scarce fossil record. The analysis of bacterial genomes remains challenging because of large sequence divergence, the plasticity of bacterial genomes due to frequent gene loss, horizontal gene transfer, and differences in selective pressure from one locus to another. Therefore, taking advantage of the rich and rapidly accumulating genomic data requires accurate modeling of genome evolution. An important technical consideration is that loci with high effective mutation rates may diverge beyond the detection limit of the alignment algorithms used, biasing the genome-wide divergence estimates toward smaller divergences. In this article, we propose a novel method to gain insight into bacterial evolution b

SUBMITTER: Sheinman M 

PROVIDER: S-EPMC10990148 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature