Sjogren's syndrome and Parkinson's Disease: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have reported an association between Sjögren's syndrome (SS) and an increased risk of Parkinson's Disease (PD). However, the causal relationship between these conditions remains unclear. The objective of this study was to investigate the causal impact of SS on the risk of developing PD, utilizing the Mendelian randomization (MR) approach.

Methods

We conducted a bidirectional MR analysis using publicly available genome-wide association studies (GWAS) data. The primary analysis utilized the inverse-variance weighted (IVW) method. Complementary methods, such as MR-Egger regression, weighted mode, weighted median, and MR-pleiotropy residual sum and outlier (MR-PRESSO), were utilized to identify and correct for the presence of horizontal

SUBMITTER: Cai X 

PROVIDER: S-EPMC10990169 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature