Compartment specific responses to contractility in the small intestinal epithelium.

ABSTRACT: Tissues are subject to multiple mechanical inputs at the cellular level that influence their overall shape and function. In the small intestine, actomyosin contractility can be induced by many physiological and pathological inputs. However, we have little understanding of how contractility impacts the intestinal epithelium on a cellular and tissue level. In this study, we probed the cell and tissue-level effects of contractility by using mouse models to genetically increase the level of myosin activity in the two distinct morphologic compartments of the intestinal epithelium, the crypts and villi. We found that increased contractility in the villar compartment caused shape changes in the cells that expressed the transgene and their immediate neighbors. While there were no discernable effec

SUBMITTER: Hinnant T 

PROVIDER: S-EPMC10990186 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature