Causality of genetically determined blood metabolites on irritable bowel syndrome: A Mendelian randomization study.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders and dysmetabolism plays an important role in the pathogenesis of disease. Nevertheless, there remains a lack of information regarding the causal relationship between circulating metabolites and IBS. A two-sample Mendelian randomization (MR) analysis was conducted in order to evaluate the causal relationship between genetically proxied 486 blood metabolites and IBS.

Methods

A two-sample MR analysis was implemented to assess the causality of blood metabolites on IBS. The study utilized a genome-wide association study (GWAS) to examine 486 metabolites as the exposure variable while employing a GWAS study with 486,601 individuals of European descent as the outcome variable. The inverse

SUBMITTER: Dai X 

PROVIDER: S-EPMC10990233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature