A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in <i>C. elegans</i> via p38-MAPK.

ABSTRACT: Organisms across taxa face stresses including variable temperature, redox imbalance, and xenobiotics. Successfully responding to stress and restoring homeostasis are crucial for survival. Aging is associated with a decreased stress response and alterations in the microbiome, which contribute to disease development. Animals and their microbiota share their environment; however, microbes have short generation time and can rapidly evolve and potentially affect host physiology during stress. Here, we leverage Caenorhabditis elegans and its simplified bacterial diet to demonstrate how microbial adaptation to oxidative stress affects the host's lifespan and stress response. We find that worms fed stress-evolved bacteria exhibit enhanced stress resistance and an extended lifespan. Through

SUBMITTER: Bhat A 

PROVIDER: S-EPMC10990273 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature