Histone variant H2A.Z and linker histone H1 influence chromosome condensation in Saccharomyces cerevisiae.

ABSTRACT: Chromosome condensation is essential for the fidelity of chromosome segregation during mitosis and meiosis. Condensation is associated both with local changes in nucleosome structure and larger-scale alterations in chromosome topology mediated by the condensin complex. We examined the influence of linker histone H1 and variant histone H2A.Z on chromosome condensation in budding yeast cells. Linker histone H1 has been implicated in local and global compaction of chromatin in multiple eukaryotes, but we observe normal condensation of the rDNA locus in yeast strains lacking H1. However, deletion of the yeast HTZ1 gene, coding for variant histone H2A.Z, causes a significant defect in rDNA condensation. Loss of H2A.Z does not change condensin association with the rDNA locus or significantly aff

SUBMITTER: Rogers AM 

PROVIDER: S-EPMC10990423 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature