Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis.

ABSTRACT: Endocycling cells grow and repeatedly duplicate their genome without dividing. Cells switch from mitotic cycles to endocycles in response to developmental signals during the growth of specific tissues in a wide range of organisms. The purpose of switching to endocycles, however, remains unclear in many tissues. Additionally, cells can switch to endocycles in response to conditional signals, which can have beneficial or pathological effects on tissues. However, the impact of these unscheduled endocycles on development is underexplored. Here, we use Drosophila ovarian somatic follicle cells as a model to examine the impact of unscheduled endocycles on tissue growth and function. Follicle cells normally switch to endocycles at mid-oogenesis. Inducing follicle cells to prematurely switch to en

SUBMITTER: Herriage HC 

PROVIDER: S-EPMC10990429 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature