Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses.

ABSTRACT: Our understanding of mitochondrial signaling in the nervous system has been limited by the technical challenge of analyzing mitochondrial function in vivo. In the transparent genetic model Caenorhabditis elegans, we were able to manipulate and measure mitochondrial reactive oxygen species (mitoROS) signaling of individual mitochondria as well as neuronal activity of single neurons in vivo. Using this approach, we provide evidence supporting a novel role for mitoROS signaling in dendrites of excitatory glutamatergic C. elegans interneurons. Specifically, we show that following neuronal activity, dendritic mitochondria take up calcium (Ca²⁺) via the mitochondrial Ca²⁺ uniporter (MCU-1) that results in an upregulation of mitoROS production. We also observed

SUBMITTER: Doser RL 

PROVIDER: S-EPMC10990490 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature