Divergent effects of switching from cytology to HPV-based screening in the Nordic countries.

ABSTRACT:

Background

Cervical cytology has been the primary method of cervical cancer screening for decades. Tests that detect viral HPV are shown in several randomized trials to provide better protection against cancer compared with cytology. HPV-based screening has been implemented alongside cytology in the Nordic countries for several years. The aim of this study was to compare cytology and HPV-based screening in the colposcopy referrals and detection rates of cervical lesions.

Methods

Individual-level screening data from Finland, Iceland, Norway and Sweden were harmonized and aggregated locally. We utilized data for tests taken during years 2015-17 and biopsies taken during years 2015-19 to allow 24 months of follow-up. Age-standardized estimates and age-adjusted risk ratios for s

SUBMITTER: Partanen VM 

PROVIDER: S-EPMC10990554 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature