Sleep and Risk of Pancreatic Cancer in the UK Biobank.

ABSTRACT:

Background

Light at night, which may cause circadian disruption, is a potential pancreatic cancer risk factor. However, evidence from related exposures such as poor sleep health and shift work remains inconclusive and sparsely investigated.

Methods

We evaluated associations between self-reported typical sleep duration, chronotype, shift work, insomnia symptoms, snoring, and daytime sleeping and pancreatic ductal adenocarcinomas (PDAC) incidence among 475,286 UK Biobank participants. We used Cox proportional hazards models to estimate HRs and 95% confidence intervals (CI) adjusting for age, sex, body mass index, smoking status, duration, and frequency, alcohol intake, diabetes status, race, and employment/shift work.

Results

Over 14 years of follow-up, 1,079 adults wer

SUBMITTER: Freeman JR 

PROVIDER: S-EPMC10990775 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature