Compartmentalized ocular lymphatic system mediates eye-brain immunity.

ABSTRACT: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina¹. Still, the possibility of an immunological nexus between the posterior eye and the rest of the CNS tissues remains unexplored. Here, studying immune responses to herpes simplex virus in the brain, we observed that intravitreal immunization protects mice against intracranial viral challenge. This protection extended to bacteria and even tumours, allowing therapeutic immune responses against glioblastoma through intravitreal immunization. We further show that the anterior and posterior compartments of the eye have distinct lymphatic dra

SUBMITTER: Yin X 

PROVIDER: S-EPMC10990932 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature