NF2 mutation status and tumor mutational burden correlate with immune cell infiltration in meningiomas.

ABSTRACT:

Background

The tumor microenvironment is an emerging biomarker of underlying genomic heterogeneity and response to immunotherapy-based treatment regimens in solid malignancies. How tumor mutational burden influences the density, distribution, and presence of a localized immune response in meningiomas is unknown.

Methods

Representative hematoxylin and eosin slides were reviewed at 40X to assess for the density of inflammatory cells. Lymphocytes and macrophages were quantified in the following ordinal manner: 0 = not present, 1 = 1-25 cells present, and 2 = greater than 26 cells present. Immune cell infiltrate grade was scored for both scattered and aggregated distributions. Next generation targeted sequencing was performed on all meningiomas included in this study.

Results

SUBMITTER: Rutland JW 

PROVIDER: S-EPMC10991085 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature