Synergistic induction of tertiary lymphoid structures by chemoimmunotherapy in bladder cancer.

ABSTRACT:

Background

A substantial number of patients with bladder cancer fail to benefit from immune checkpoint inhibitors (ICIs). We aim to investigate whether the addition of other therapeutic modalities into immunotherapy may augment the immune reactivity, thereby improving the overall response rate.

Methods

We conducted a comprehensive assessment of the immunological changes following immunotherapy and chemotherapy, employing both single-cell RNA sequencing and bulk RNA sequencing analyses.

Results

The bladder cancer patient treated with ICIs exhibited a higher abundance of B cells and T follicular helper cells compared to the treatment-naïve patient. Analysis of public datasets and the in-house RJBLC-I2N003 cohort revealed the induction of tertiary lymphoid structure (TLS

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10991273 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature