Strategies to improve implementation of cascade testing in hereditary cancer syndromes: a systematic review.

ABSTRACT: Hereditary cancer syndromes constitute approximately 10% of all cancers. Cascade testing involves testing of at-risk relatives to determine if they carry the familial pathogenic variant. Despite growing efforts targeted at improving cascade testing uptake, current literature continues to reflect poor rates of uptake, typically below 30%. This study aims to systematically review current literature on intervention strategies to improve cascade testing, assess the quality of intervention descriptions and evaluate the implementation outcomes of listed interventions. We searched major databases using keywords and subject heading of "cascade testing". Interventions proposed in each study were classified according to the Effective Practice and Organization of Care (EPOC) taxonomy. Quality of inte

SUBMITTER: Chiang J 

PROVIDER: S-EPMC10991315 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature