Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8⁺ T cell infiltration.

ABSTRACT:

Background

Leiomyosarcomas are among the most common histological types of soft tissue sarcoma (STS), with no effective treatment available for advanced patients. Lung metastasis, the most common site of distant metastasis, is the primary prognostic factor. We analysed the immune environment targeting lung metastasis of STS to explore new targets for immunotherapy.

Methods

We analysed the immune environment of primary and lung metastases in 38 patients with STS using immunohistochemistry. Next, we performed gene expression analyses on primary and lung metastatic tissues from six patients with leiomyosarcoma. Using human leiomyosarcoma cell lines, the effects of the identified genes on immune cells were assessed in vitro.

Results

Immunohistochemistry showed a significa

SUBMITTER: Kanahori M 

PROVIDER: S-EPMC10991329 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature