Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations.

ABSTRACT: SARS CoV-2, the causative agent for the ongoing COVID-19 pandemic, it enters the host cell by activating the ACE2 receptor with the help of two proteasesi.e., Furin and TMPRSS2. Therefore, variations in these genes may account for differential susceptibility and severity between populations. Previous studies have shown that the role of ACE2 and TMPRSS2 gene variants in understanding COVID-19 susceptibility among Indian populations. Nevertheless, a knowledge gap exists concerning the COVID-19 susceptibility of Furin gene variants among diverse South Asian ethnic groups. Investigating the role of Furin gene variants and their global phylogeographic structure is essential to comprehensively understanding COVID-19 susceptibility in these populations. We have used 450 samples from diverse India

SUBMITTER: Pandey RK 

PROVIDER: S-EPMC10991378 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature