Dataset Information

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study.

ABSTRACT:

Background

No reliable marker has been identified to predict postoperative recurrence of gastric cancer. We designed a clinical trial to investigate the utility of serum NY-ESO-1 antibody responses as a predictive marker for postoperative recurrence in gastric cancer.

Methods

A multicenter prospective study was conducted between 2012 and 2021. Patients with resectable cT3-4 gastric cancer were included. Postoperative NY-ESO-1 and p53 antibody responses were serially evaluated every 3 months for 1 year in patients with positive preoperative antibody responses. The recurrence rate was assessed by the positivity of antibody responses at 3 and 12 months postoperatively.

Results

Among 1001 patients, preoperative NY-ESO-1 and p53 antibody responses were positive in 12.6% and 18.1% of patients, respectively. NY-ESO-1 antibody responses became negative postoperatively in non-recurrent patients (negativity rates; 45% and 78% at 3 and 12 months, respectively), but remained positive in recurrent patients (negativity rates; 9% and 8%, respectively). p53 antibody responses remained positive in non-recurrent patients. In multivariate analysis, NY-ESO-1 antibody positivity at 3 months (P < 0.03) and 12 months (P < 0.001) were independent prognostic factors for a shorter recurrence-free interval.

Conclusions

Serum NY-ESO-1 antibodies may be a useful predictive marker for postoperative recurrence in gastric cancer.

Clinical trial registration

UMIN000007925.

SUBMITTER: Saito T

PROVIDER: S-EPMC10991393 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study.

Saito Takuro T Kurokawa Yukinori Y Fujitani Kazumasa K Kawabata Ryohei R Takeno Atsushi A Mikami Jota J Endo Shunji S Matsuyama Jin J Akamaru Yusuke Y Hirota Masashi M Kishi Kentaro K Urakawa Shinya S Yamamoto Kei K Tanaka Koji K Takahashi Tsuyoshi T Oka Mikio M Wada Hisashi H Eguchi Hidetoshi H Doki Yuichiro Y

British journal of cancer 20240207 7

<h4>Background</h4>No reliable marker has been identified to predict postoperative recurrence of gastric cancer. We designed a clinical trial to investigate the utility of serum NY-ESO-1 antibody responses as a predictive marker for postoperative recurrence in gastric cancer.<h4>Methods</h4>A multicenter prospective study was conducted between 2012 and 2021. Patients with resectable cT3-4 gastric cancer were included. Postoperative NY-ESO-1 and p53 antibody responses were serially evaluated ever ...[more]

PMID: 38326601

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Dataset Information

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study.

Background

Methods

Results

Conclusions

Clinical trial registration

Publications

Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study.

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