Tumor microenvironment is associated with clinical and genetic properties of diffuse gliomas and predicts overall survival.

ABSTRACT: Tumor microenvironment (TME) is a complex and dynamic evolving environment which facilitates tumor proliferation and progression. We aimed at investigating the characteristics of tumor microenvironment and its prognostic value in gliomas. Transcriptome data of 702 glioma samples from The Cancer Genome Atlas were included as training dataset, while 325 samples from Chinese Glioma Genome Atlas database and 268 samples from GSE16011 database were used to validate. We found that the infiltration of stromal and immune cell varied in gliomas of different grades and pathological types, and was associated with poor prognosis. Based on the gene expression profile, we constructed a TME-related signature (TMERS), which was closely related to clinical features and genomic variation of gliomas. In TMER

SUBMITTER: Wang QW 

PROVIDER: S-EPMC10991563 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature