Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study.

ABSTRACT: Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases through the intricate interplay between gut microbiota and the host. However, the precise nature of the causal link between gut microbiota and hypertrophic scarring remains uncertain. In this study, after compiling summary data from genome-wide association studies (GWAS) involving 418 instances of gut microbiota and hypertrophic scarring, we conducted a bidirectional Mendelian randomization (MR) to investigate the potential existence of a causal relationship between gut microbiota and the develo

SUBMITTER: Xue K 

PROVIDER: S-EPMC10991740 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature