Mycobacterium bovis BCG as immunostimulating agent prevents the severe form of chronic experimental Chagas disease.

ABSTRACT:

Introduction

There is currently no vaccine against Chagas disease (ChD), and the medications available confer multiple side effects. Mycobacterium bovis Bacillus Calmette-Guérin (BCG) produces balanced Th1, Th2, and Th17 modulatory immune responses and has improved efficacy in controlling chronic infections through nonspecific immunity. We aimed to improve the response to infection by inducing a stronger immune response and greater protection against the parasite by trained immunity.

Methods

BALB/c mice were immunized with BCG subcutaneously, and 60 days later, they were infected with Trypanosoma cruzi intraperitoneally. An evaluation of the progression of the disease from the acute to the chronic stage, analyzing various aspects such as parasitemia, survival,

SUBMITTER: Arce-Fonseca M 

PROVIDER: S-EPMC10991741 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature