Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.

ABSTRACT:

Introduction

It is well-known that circulating microRNAs (miRNAs) play a relevant role in many kinds of diseases by regulating the expression of genes involved in various pathophysiologic processes, including erectile dysfunction (ED) and cardiovascular diseases (CVD).

Purpose

This study aimed to identify the miRNA-21 profile in the blood samples of patients with ED, CVD, and the combination of both pathologies to elucidate the potential function of miRNA-21.

Methods

A total of 45 patients with CVD and/or who underwent the erectile function test were included and divided into the following categories: CVD with ED (cases, n = 29) and controls (n = 16) with either ED or CVD. Real-time polymerase chain reaction analysis verified the results. miRNA-21 expres

SUBMITTER: Agullo L 

PROVIDER: S-EPMC10991794 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature