Impaired amygdala astrocytic signaling worsens neuropathic pain-associated neuronal functions and behaviors.

ABSTRACT: Introduction: Pain is a clinically relevant health care issue with limited therapeutic options, creating the need for new and improved analgesic strategies. The amygdala is a limbic brain region critically involved in the regulation of emotional-affective components of pain and in pain modulation. The central nucleus of amygdala (CeA) serves major output functions and receives nociceptive information via the external lateral parabrachial nucleus (PB). While amygdala neuroplasticity has been linked causally to pain behaviors, non-neuronal pain mechanisms in this region remain to be explored. As an essential part of the neuroimmune system, astrocytes that represent about 40-50% of glia cells within the central nervous system, are required for physiological neuronal functions, but thei

SUBMITTER: Mazzitelli M 

PROVIDER: S-EPMC10991799 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature