Sensory neuron transient receptor potential vanilloid-1 channel regulates angiogenesis through CGRP in vivo.

ABSTRACT: Angiogenesis plays a key role in bone regeneration. The role of neurons of peripheral nerves involved in angiogenesis of bone defects needs to be explored. The transient receptor potential vanilloid 1 (TRPV1), a nociceptor of noxious stimuli, is expressed on sensory neurons. Apart from nociception, little is known about the role of sensory innervation in angiogenesis. Calcitonin gene-related peptide (CGRP), a neuropeptide secreted by sensory nerve terminals, has been associated with vascular regeneration. We characterized the reinnervation of vessels in bone repair and assessed the impact of TRPV1-CGRP signaling on early vascularization. We investigated the pro-angiogenic effect of neuronal TRPV1 in the mouse model of femur defect. Micro-CT analysis with Microfil^® reagent perfus

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10991839 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature