Decoding the genetic links between serum lipidomic profile, amino acid biomarkers, and programmed cell death protein-1/programmed cell death-ligand-1.

ABSTRACT:

Background

Disruptions in lipid metabolism and amino acids have been increasingly linked to resistance to immunotherapy. However, the underlying mechanisms by which dysregulated serum lipid metabolism and amino acids affect the efficacy of immunotherapies through PD-1/PD-L1 expression and function remain poorly understood.

Methods

To elucidate the potential associations between lipid metabolism, amino acids, and PD-1/PD-L1, we employed the powerful Mendelian randomization (MR) method, leveraging large-scale genome-wide association studies.

Results

In the present MR study, we identified a noteworthy negative association between alanine and PD-1 expression, implicating a regulatory role for alanine metabolism in modulating the immune response to cancer treatment. Additi

SUBMITTER: Li W 

PROVIDER: S-EPMC10992168 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature