The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms.

ABSTRACT: Dysfunctional anti-tumor immunity has been implicated in the pathogenesis of mature B cell neoplasms, such as multiple myeloma and B cell lymphoma; however, the impact of exhausted T cells on disease development remains unclear. Therefore, the present study investigated the features and pathogenetic significance of exhausted T cells using a mouse model of de novo mature B cell neoplasms, which is likely to show immune escape similar to human patients. The results revealed a significant increase in PD-1⁺ Tim-3^- and PD-1⁺ Tim-3⁺ T cells in sick mice. Furthermore, PD-1⁺ Tim-3⁺ T cells exhibited direct cytotoxicity with a short lifespan, showing transcriptional similarities to terminally exhausted T cells. On the other hand, PD-

SUBMITTER: Shibamiya A 

PROVIDER: S-EPMC10992361 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature