Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy.

ABSTRACT: Tumor immunogenicity is driven by various genomic and transcriptomic factors but the association with the overall status of methylation aberrancy is not well established. We analyzed The Cancer Genome Atlas pan-cancer database to investigate whether the overall methylation aberrancy links to the immune evasion of tumor. We created the definitions of hypermethylation burden, hypomethylation burden and methylation burden to establish the values that represent the degree of methylation aberrancy from human methylation 450 K array data. Both hypermethylation burden and hypomethylation burden significantly correlated with global methylation level as well as methylation subtypes defined in previous literatures. Then we evaluated whether methylation burden correlates with tumor immunogenicity and

SUBMITTER: Park C 

PROVIDER: S-EPMC10992373 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature