Exploring lncRNA Expression Patterns in Patients With Hypertrophied Ligamentum Flavum.

ABSTRACT:

Objective

Hypertrophy ligamentum flavum (LFH) is a common cause of lumbar spinal stenosis, resulting in significant disability and morbidity. Although long noncoding RNAs (lncRNAs) have been associated with various biological processes and disorders, their involvement in LFH remains not fully understood.

Methods

Human ligamentum flavum samples were analyzed using lncRNA sequencing followed by validation through quantitative real-time polymerase chain reaction. To explore the potential biological functions of differentially expressed lncRNA-associated genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. We also studied the impact of lncRNA PARD3-AS1 on the progression of LFH in vitro.

Results

In the LFH tissues w

SUBMITTER: Chen J 

PROVIDER: S-EPMC10992663 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature