Predicting responses to omalizumab in antihistamine-refractory chronic urticaria: A real-world longitudinal study.

ABSTRACT:

Background

Treating chronic urticaria (CU) that is unresponsive to H1-antihistamines (H1AHs) is challenging, and the real-world effectiveness of omalizumab remains unclear.

Objective

Our aim was to evaluate the real-world effectiveness of omalizumab, optimal response assessment timing, and predictive factors.

Methods

Initially, 5535 patients with CU who were receiving at least 20 mg of loratadine daily for at least 6 months (January 2007-August 2021) were screened. Ultimately, 386 patients who had been receiving omalizumab add-on treatment for >6 months were followed-up for more than 2 years. Predictors of treatment response to omalizumab add-on therapy for patients with antihistamine-refractory CU were identified by using a generalized linear model.

Results

In

SUBMITTER: Lee HY 

PROVIDER: S-EPMC10992700 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature