Ontology highlight
ABSTRACT:
SUBMITTER: Parhiz H
PROVIDER: S-EPMC10992703 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Parhiz Hamideh H Shuvaev Vladimir V VV Li Qin Q Papp Tyler E TE Akyianu Awurama A AA Shi Ruiqi R Yadegari Amir A Shahnawaz Hamna H Semple Sean C SC Mui Barbara L BL Weissman Drew D Muzykantov Vladimir R VR Glassman Patrick M PM
Molecular therapy. Nucleic acids 20240318 2
RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the significant delay between the kinetics of RNA delivery and the onset of pharmacologic response. To bridge this gap, we have developed a physiologically based PK/pharmacodynamic model for systemically administered mRNA-containing lipid nanoparticles (LN ...[more]