Associations of urinary fetuin-A with histopathology and kidney events in biopsy-proven kidney disease.

ABSTRACT:

Background

Fetuin-A is implicated in the pathogenesis of vascular calcification in chronic kidney disease (CKD); however, the relationship between fetuin-A, histopathologic lesions and long-term kidney outcomes in patients with various types of kidney disease remains unclear.

Methods

We measured urinary fetuin-A levels in 335 individuals undergoing clinically indicated native kidney biopsy. The expressions of fetuin-A mRNA and protein in the kidney were assessed using RNA sequencing and immunohistochemistry. The association of urinary fetuin-A with histopathologic lesions and major adverse kidney events (MAKE), defined as a decline in estimated glomerular filtration rate (eGFR) of at least 40%, kidney failure or death, was analyzed.

Results

Urinary fetuin-A lev

SUBMITTER: Tsai MT 

PROVIDER: S-EPMC10993056 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature