Socioecologic Factors and Racial Differences in Breast Cancer Multigene Prognostic Scores in US Women.

ABSTRACT:

Importance

Disproportionately aggressive tumor biology among non-Hispanic Black women with early-stage, estrogen receptor (ER)-positive breast cancer contributes to racial disparities in breast cancer mortality. It is unclear whether socioecologic factors underlie racial differences in breast tumor biology.

Objective

To examine individual-level (insurance status) and contextual (area-level socioeconomic position and rural or urban residence) factors as possible mediators of racial and ethnic differences in the prevalence of ER-positive breast tumors with aggressive biology, as indicated by a high-risk gene expression profile.

Design, setting, and participants

This retrospective cohort study included women 18 years or older diagnosed with stage I to II, ER-positive bre

SUBMITTER: Parab AZ 

PROVIDER: S-EPMC10993076 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature