Susceptibility to Treatment-Resistant Depression Within Families.

ABSTRACT:

Importance

Antidepressant responses and the phenotype of treatment-resistant depression (TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD phenotype and other psychiatric disorders has also been established in previous genetic studies, but population-based cohort studies have not yet provided evidence to support these outcomes.

Objective

To estimate the TRD susceptibility and the susceptibility between TRD and other psychiatric disorders within families in a nationwide insurance cohort with extremely high coverage and comprehensive health care data.

Design, setting, and participants

This cohort study assessed data from the Taiwan national health insurance database across entire population (N = 26 554 001) between January 2003 and Decemb

SUBMITTER: Cheng CM 

PROVIDER: S-EPMC10993159 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature