Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France.

ABSTRACT:

Background

No study has compared the virological and immunological status of young people with perinatally-acquired HIV infection (P-HIV) with that of people with HIV adulthood (A-HIV) having a similar duration of infection.

Methods

5 French cohorts of P-HIV and A-HIV patients with a known date of HIV-infection and receiving antiretroviral treatment (ART), were used to compare the following proportions of: virological failure (VF) defined as plasma HIV RNA ≥ 50 copies/mL, CD4 cell percentages and CD4:CD8 ratios, at the time of the most recent visit since 2012. The analysis was stratified on time since infection, and multivariate models were adjusted for demographics and treatment history.

Findings

310 P-HIV were compared to 1515 A-HIV (median current ages 20.9 [IQR:14

SUBMITTER: Seng R 

PROVIDER: S-EPMC10993179 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature