Ontology highlight
ABSTRACT:
SUBMITTER: Zahid LU
PROVIDER: S-EPMC10993276 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Zahid Lutf Ullah LU Zaib Sumera S Saeed Aamer A Alharbi Hussam Y HY Aljohani Majed S MS Alharbi Osama O Rana Nehal N Khan Imtiaz I Shabir Ghulam G Ahmed Atteeque A Saleem Arslan A Awwad Nasser S NS Ibrahium Hala A HA
ACS omega 20240320 13
In the present work, 2-imino-1,3-thiazolines featuring highly fluorinated fragments were synthesized through a straightforward cyclization of diversely substituted thioureas with 2-bromo-1-(4-fluorophenyl)ethan-1-one. The target compounds were obtained in good yields, and structures were established by FTIR and <sup>1</sup>H- and <sup>13</sup>C NMR spectroscopic methods. The in vitro biological assay revealed that all the compounds significantly obstruct the α-glucosidase. Compound <b>6d</b> (3- ...[more]