New benzimidazole derivative compounds with in vitro fasciolicidal properties.

ABSTRACT:

Background

Control of the zoonotic food-borne parasite Fasciola hepatica remains a major challenge in humans and livestock. It is estimated that annual economic losses due to fasciolosis can reach US$3.2 billion in agriculture and livestock. Moreover, the wide distribution of drug-resistant parasite populations and the absence of a vaccine threaten sustainable control, reinforcing the need for novel flukicides.

Methods

The present work analyses the flukicidal activity of a total of 70 benzimidazole derivatives on different stages of F. hepatica. With the aim to select the most potent ones, and screenings were first performed on eggs at decreasing concentrations ranging from 50 to 5 µM and then on adult worms at 10 µM. Only the most effective compounds were also evaluated usi

SUBMITTER: Valderas-Garcia E 

PROVIDER: S-EPMC10993450 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature