Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study.

ABSTRACT:

Background

The causal relationship between maternal smoking in pregnancy and reduced offspring birth weight is well established and is likely due to impaired placental function. However, observational studies have given conflicting results on the association between smoking and placental weight. We aimed to estimate the causal effect of newly pregnant mothers quitting smoking on their placental weight at the time of delivery.

Methods

We used one-sample Mendelian randomization, drawing data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (N = 690 to 804) and the Norwegian Mother, Father and Child Cohort Study (MoBa) (N = 4267 to 4606). The sample size depends on the smoking definition used for different analyses. The analysis was performed in pre-pregnancy s

SUBMITTER: Jaitner A 

PROVIDER: S-EPMC10993495 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature